The " Rewind Direction " refers to which way the label printing is "right side up" as you unroll your labels to apply them to your products. If you are hand applying your labels, rewind #2 or #3 is most common for right handers, and rewind #4 is the favorite left handers. See below for a visual illustration of all eight (8) of the rewind directions possible. https://www.4over4.com/printing/roll-label-printing