First, make sure the new document is created and opened at the correct bleed size. Also, make sure the document is in CMYK and set to 300 dpi. If working in Photoshop please make sure to flatten the layers before sending it to 4OVER4. If you are working in a vector-based program (ex: Illustrator) we recommend you outline all your text prior to saving and sending us the artwork. Additionally, crop marks and registration marks are not necessary so avoid including them. We also recommend that all transparencies be flattened and overprint be turned off.